The medical community has been well aware of sepsis for a very long time. In 1991, the American College of Chest Physicians (ACCP) and the Society of Critical Care Medicine (SCCM) convened a “Consensus Conference” to provide a conceptual definition of systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock. They met again in 2001 and, most recently, in 2016.
Sepsis stems from an already-occurring infection, typically bacterial; however, fungal and viral infections are also common precursors. Sepsis is clinically defined as your body’s abnormal response to an infection.
If you have sepsis, your body turns on itself and starts attacking cells, tissues, and organs via the bloodstream instead of attacking the microorganisms causing the infection. Depending on its severity, sepsis can damage entire organ systems.
When sepsis is not treated promptly, a patient can go into severe sepsis and then septic shock. Septic shock presents a drastic decrease in blood pressure requiring medications such as vasopressor medications to bring the blood pressure to a safe range, typically 65 mm Hg (Mean Arterial Pressure). Vasopressors may save the patient’s life, but they may do so at the expense of the patient’s arms and legs. Early treatment using aggressive antibiotics and large amounts of intravenous fluids drastically improves chances of survival.
Early Warning Signs of Sepsis
The early warning signs that doctors should be aware of are high heart rate and fever, shivering, or feeling very cold. Once sepsis sets in, common symptoms include:
- Fever
- Chills
- Rapid breathing
- Rapid heart rate
- Rash
- Confusion
- Disorientation
- Clammy or sweaty skin
- Shortness of breath
- Extreme pain or discomfort
- A feeling of imminent death